HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-hydrazine → 1-(4-Difluoromethoxy-phenyl)-3-[2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2,3-Dihydro-benzo[1,4]dioxin-6-yl)-hydrazine | HCID 5164485 | — |
| Reactant | 1-(4-Difluoromethoxy-phenyl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one | HCID 59369978 | — |
| Product | 1-(4-Difluoromethoxy-phenyl)-3-[2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one | HCID 59370018 | 33% |
Reaction Steps
The product was obtained starting from 1-(4-Difluoromethoxy-phenyl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one (A-9) and (2,3-dihydro-benzo[1,4]dioxin-6-yl)-hydrazine according to the method described for Example 91 in 33% yield. MS: M=439.1 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178538B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-4cf4108fb617497981fa0b3d22941b23 |
| Source note | uspto-grants-2012_05 |