(3-Fluorophenyl)hydrazine → 1-Benzo[1,3]dioxol-4-yl-3-[2-(3-fluoro-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

HRID 1924588Notes

Reaction equation

HRID 1924588 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([N:10]3[CH:15]=[CH:14][C:13](=[O:16])[C:12]([C:17](=O)/[CH:18]=[CH:19]/[N:20](C)C)=[N:11]3)[C:4]=2[O:3][CH2:2]1.[F:24][C:25]1[CH:26]=[C:27]([NH:31]N)[CH:28]=[CH:29][CH:30]=1>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([N:10]3[CH:15]=[CH:14][C:13](=[O:16])[C:12]([C:17]4[N:31]([C:27]5[CH:28]=[CH:29][CH:30]=[C:25]([F:24])[CH:26]=5)[N:20]=[CH:19][CH:18]=4)=[N:11]3)[C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 581026(3-Fluorophenyl)hydrazineHCID 593700051-Benzo[1,3]dioxol-4-yl-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one

Product 1

HCID 462201501-Benzo[1,3]dioxol-4-yl-3-[2-(3-fluoro-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

Procedure

The product was obtained starting from 1-Benzo[1,3]dioxol-4-yl-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one (A-14) and 3-fluoro-phenylhydrazine according to the method described for example 91. MS: M=377.2 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-2d83d36ed3084c3d8c141015ff1fac1e
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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