2,5-Difluorophenylhydrazine → 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-3-[2-(2,5-difluoro-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

HRID 1924591Notes

Reaction equation

HRID 1924591 reaction equation
[F:1][C:2]1([F:25])[O:6][C:5]2[CH:7]=[CH:8][C:9]([N:11]3[CH:16]=[CH:15][C:14](=[O:17])[C:13]([C:18](=O)/[CH:19]=[CH:20]/[N:21](C)C)=[N:12]3)=[CH:10][C:4]=2[O:3]1.[F:26][C:27]1[CH:32]=[CH:31][C:30]([F:33])=[CH:29][C:28]=1[NH:34]N>>[F:1][C:2]1([F:25])[O:6][C:5]2[CH:7]=[CH:8][C:9]([N:11]3[CH:16]=[CH:15][C:14](=[O:17])[C:13]([C:18]4[N:34]([C:28]5[CH:29]=[C:30]([F:33])[CH:31]=[CH:32][C:27]=5[F:26])[N:21]=[CH:20][CH:19]=4)=[N:12]3)=[CH:10][C:4]=2[O:3]1

Participants

3

Reactant 2

HCID 5889572,5-DifluorophenylhydrazineHCID 593701531-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one

Product 1

HCID 593699571-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-3-[2-(2,5-difluoro-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

Procedure

The product was obtained starting from 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one (A-11) and 2,5-difluoro-phenylhydrazine according to the method described for example 91. MS: M=431.2 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-c9efac6df30341ff9b0ecb8fb82a51e1
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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