4-Hydrazino-2-methylpyridine → 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-3-[2-(2-methyl-pyridin-4-yl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

HRID 1924604Notes

Reaction equation

HRID 1924604 reaction equation
[F:1][C:2]1([F:25])[O:6][C:5]2[CH:7]=[CH:8][C:9]([N:11]3[CH:16]=[CH:15][C:14](=[O:17])[C:13]([C:18](=O)/[CH:19]=[CH:20]/N(C)C)=[N:12]3)=[CH:10][C:4]=2[O:3]1.[NH:26]([C:28]1[CH:33]=[CH:32][N:31]=[C:30]([CH3:34])[CH:29]=1)[NH2:27]>>[F:25][C:2]1([F:1])[O:6][C:5]2[CH:7]=[CH:8][C:9]([N:11]3[CH:16]=[CH:15][C:14](=[O:17])[C:13]([C:18]4[N:26]([C:28]5[CH:33]=[CH:32][N:31]=[C:30]([CH3:34])[CH:29]=5)[N:27]=[CH:20][CH:19]=4)=[N:12]3)=[CH:10][C:4]=2[O:3]1

Participants

3

Reactant 2

HCID 200736634-Hydrazino-2-methylpyridineHCID 593701531-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one

Product 1

HCID 593699911-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-3-[2-(2-methyl-pyridin-4-yl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

Procedure

The product was obtained starting from 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one (A-11) and 4-hydrazino-2-methylpyridine according to the method described for example 91. MS: M=410.2 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-96ef848ad7f149e880b9e77273bb32fd
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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