4-Hydrazino-2-methylpyridine → 1-(3-Fluoro-phenyl)-3-[2-(2-methyl-pyridin-4-yl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

HRID 1924606Notes

Reaction equation

HRID 1924606 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[CH:15]=2)[N:8]=1)=O.[NH:22]([C:24]1[CH:29]=[CH:28][N:27]=[C:26]([CH3:30])[CH:25]=1)N>>[F:20][C:16]1[CH:15]=[C:14]([N:9]2[CH:10]=[CH:11][C:12](=[O:13])[C:7]([C:5]3[N:22]([C:24]4[CH:29]=[CH:28][N:27]=[C:26]([CH3:30])[CH:25]=4)[N:2]=[CH:3][CH:4]=3)=[N:8]2)[CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 200736634-Hydrazino-2-methylpyridineHCID 593699513-((E)-3-Dimethylamino-acryloyl)-1-(3-fluoro-phenyl)-1H-pyridazin-4-one

Product 1

HCID 593699591-(3-Fluoro-phenyl)-3-[2-(2-methyl-pyridin-4-yl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(3-fluoro-phenyl)-1H-pyridazin-4-one (A-13) and 4-hydrazino-2-methylpyridine according to the method described for example 91. MS: M=348.2 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-4c522f96292245858b121f5f006ee426
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

Loading…