[3-(Trifluoromethoxy)phenyl]hydrazine → 1-(4-Trifluoromethoxy-phenyl)-3-[2-(3-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

HRID 1924614Notes

Reaction equation

HRID 1924614 reaction equation
CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=2)[N:8]=1)=O.[F:26][C:27]([F:38])([F:37])[O:28][C:29]1[CH:30]=[C:31]([NH:35][NH2:36])[CH:32]=[CH:33][CH:34]=1>>[F:24][C:21]([F:22])([F:23])[O:20][C:17]1[CH:18]=[CH:19][C:14]([N:9]2[CH:10]=[CH:11][C:12](=[O:13])[C:7]([C:5]3[N:35]([C:31]4[CH:32]=[CH:33][CH:34]=[C:29]([O:28][C:27]([F:37])([F:38])[F:26])[CH:30]=4)[N:36]=[CH:3][CH:4]=3)=[N:8]2)=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 5194226[3-(Trifluoromethoxy)phenyl]hydrazineHCID 593700343-((E)-3-Dimethylamino-acryloyl)-1-(4-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

Product 1

HCID 593700481-(4-Trifluoromethoxy-phenyl)-3-[2-(3-trifluoromethoxy-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(4-trifluoromethoxy-phenyl)-1H-pyridazin-4-one (A-8) and 3-trifluoromethoxy-phenylhydrazine according to the method described for example 91. MS: M=483.2 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-945c1832667a48fe9971e65dc34f8ad9
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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