(3-Fluorophenyl)hydrazine → 3-[2-(3-Fluoro-phenyl)-2H-pyrazol-3-yl]-1-(4-methanesulfonyl-phenyl)-1H-pyridazin-4-one

HRID 1924626Notes

Reaction equation

HRID 1924626 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][C:17]([S:20]([CH3:23])(=[O:22])=[O:21])=[CH:16][CH:15]=2)[N:8]=1)=O.[F:25][C:26]1[CH:27]=[C:28]([NH:32]N)[CH:29]=[CH:30][CH:31]=1>>[F:25][C:26]1[CH:27]=[C:28]([N:32]2[C:5]([C:7]3[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]4[CH:19]=[CH:18][C:17]([S:20]([CH3:23])(=[O:22])=[O:21])=[CH:16][CH:15]=4)[N:8]=3)=[CH:4][CH:3]=[N:2]2)[CH:29]=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 581026(3-Fluorophenyl)hydrazineHCID 593701413-((E)-3-Dimethylamino-acryloyl)-1-(4-methansulfonyl-phenyl)-1H-pyridazin-4-one

Product 1

HCID 593700383-[2-(3-Fluoro-phenyl)-2H-pyrazol-3-yl]-1-(4-methanesulfonyl-phenyl)-1H-pyridazin-4-one

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(4-methansulfonyl-phenyl)-1H-pyridazin-4-one (A-16) and 3-fluoro-phenylhydrazine according to the method described for example 43. MS: M=411.1 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-18a7ebb7994c473898a9b8b085600191
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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