(3-Methanesulfonylphenyl)hydrazine → 1-(4-Difluoromethoxy-phenyl)-3-[2-(3-methanesulfonyl-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

HRID 1924634Notes

Reaction equation

HRID 1924634 reaction equation
[F:1][CH:2]([F:24])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:15]=[CH:14][C:13](=[O:16])[C:12]([C:17](=O)/[CH:18]=[CH:19]/[N:20](C)C)=[N:11]2)=[CH:6][CH:5]=1.[CH3:25][S:26]([C:29]1[CH:30]=[C:31]([NH:35]N)[CH:32]=[CH:33][CH:34]=1)(=[O:28])=[O:27]>>[F:1][CH:2]([F:24])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:15]=[CH:14][C:13](=[O:16])[C:12]([C:17]3[N:35]([C:31]4[CH:32]=[CH:33][CH:34]=[C:29]([S:26]([CH3:25])(=[O:28])=[O:27])[CH:30]=4)[N:20]=[CH:19][CH:18]=3)=[N:11]2)=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 22034382(3-Methanesulfonylphenyl)hydrazineHCID 593699781-(4-Difluoromethoxy-phenyl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one

Product 1

HCID 593700491-(4-Difluoromethoxy-phenyl)-3-[2-(3-methanesulfonyl-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

Procedure

The product was obtained starting from 1-(4-Difluoromethoxy-phenyl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one (A-9) and (3-methanesulfonyl-phenyl)-hydrazine according to the method described for example 91. MS: M=459.3 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-fda2912cd0d14725bb774bd991b3c4c8
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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