(3-Methanesulfonylphenyl)hydrazine → 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-3-[2-(3-methanesulfonyl-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

HRID 1924642Notes

Reaction equation

HRID 1924642 reaction equation
[F:1][C:2]1([F:25])[O:6][C:5]2[CH:7]=[CH:8][C:9]([N:11]3[CH:16]=[CH:15][C:14](=[O:17])[C:13]([C:18](=O)/[CH:19]=[CH:20]/N(C)C)=[N:12]3)=[CH:10][C:4]=2[O:3]1.[CH3:26][S:27]([C:30]1[CH:31]=[C:32]([NH:36][NH2:37])[CH:33]=[CH:34][CH:35]=1)(=[O:29])=[O:28]>>[F:25][C:2]1([F:1])[O:6][C:5]2[CH:7]=[CH:8][C:9]([N:11]3[CH:16]=[CH:15][C:14](=[O:17])[C:13]([C:18]4[N:36]([C:32]5[CH:33]=[CH:34][CH:35]=[C:30]([S:27]([CH3:26])(=[O:29])=[O:28])[CH:31]=5)[N:37]=[CH:20][CH:19]=4)=[N:12]3)=[CH:10][C:4]=2[O:3]1

Participants

3

Reactant 2

HCID 22034382(3-Methanesulfonylphenyl)hydrazineHCID 593701531-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one

Product 1

HCID 593701481-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-3-[2-(3-methanesulfonyl-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

Procedure

The product was obtained starting from 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one (A-11) and (3-methane sulfonyl-phenyl)-hydrazine according to the method described for example 91. MS: M=473.2 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-33bca5136f6e478e9e1583e2937fb83e
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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