HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-3-[2-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | (2,2-Difluoro-benzo[1,3]dioxol-4-yl)hydrazine | HCID 55279040 | — |
| Reactant | 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one | HCID 59370153 | — |
| Product | 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-3-[2-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one | HCID 59369990 | — |
Reaction Steps
The product was obtained starting from 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-3-((E)-3-dimethylamino-acryloyl)-1H-pyridazin-4-one (A-11) and 2,2-difluoro-benzo[1,3]dioxol-4-yl-hydrazine (prepared from the corresponding amino derivative using sodium nitrite and tin(II) chloride as described in J. Med. Chem. 2003, 46, 4676-4686) according to the method described for example 91. MS: M=475.0 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178538B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-f31472b0190f41b9af675ffde91679b3 |
| Source note | uspto-grants-2012_05 |