N-(3-hydrazinylphenyl)acetamide → N-(3-{5-[1-(3-Dimethylsulfamoyl-phenyl)-4-oxo-1,4-dihydro-pyridazin-3-yl]-pyrazol-1-yl}-phenyl)-acetamide

HRID 1924650Notes

Reaction equation

HRID 1924650 reaction equation
CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:15]=[C:16]([S:20]([N:23]([CH3:25])[CH3:24])(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=2)[N:8]=1)=O.[NH:27]([C:29]1[CH:30]=[C:31]([NH:35][C:36](=[O:38])[CH3:37])[CH:32]=[CH:33][CH:34]=1)[NH2:28]>>[CH3:25][N:23]([CH3:24])[S:20]([C:16]1[CH:15]=[C:14]([N:9]2[CH:10]=[CH:11][C:12](=[O:13])[C:7]([C:5]3[N:27]([C:29]4[CH:30]=[C:31]([NH:35][C:36](=[O:38])[CH3:37])[CH:32]=[CH:33][CH:34]=4)[N:28]=[CH:3][CH:4]=3)=[N:8]2)[CH:19]=[CH:18][CH:17]=1)(=[O:21])=[O:22]

Participants

3

Reactant 2

HCID 45076296N-(3-hydrazinylphenyl)acetamideHCID 593701633-[3-((E)-3-Dimethylamino-acryloyl)-4-oxo-4H-pyridazin-1-yl]-N,N-dimethyl-benzenesulfonamide

Product 1

HCID 59370156N-(3-{5-[1-(3-Dimethylsulfamoyl-phenyl)-4-oxo-1,4-dihydro-pyridazin-3-yl]-pyrazol-1-yl}-phenyl)-acetamide

Procedure

The product was obtained starting from 3-[3-((E)-3-Dimethylamino-acryloyl)-4-oxo-4H-pyridazin-1-yl]-N,N-dimethyl-benzenesulfonamide (A-12) and N-(3-hydrazino-phenyl)-acetamide according to the method described for example 91. MS: M=479.1 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-7378712b353e4601a39e293a18748cf8
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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