5-Hydrazinylisoquinoline → 3-(2-Isoquinolin-5-yl-2H-pyrazol-3-yl)-1-(4-methanesulfonyl-phenyl)-1H-pyridazin-4-one

HRID 1924661Notes

Reaction equation

HRID 1924661 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][C:17]([S:20]([CH3:23])(=[O:22])=[O:21])=[CH:16][CH:15]=2)[N:8]=1)=O.[CH:25]1[C:34]2[C:29](=[C:30]([NH:35]N)[CH:31]=[CH:32][CH:33]=2)[CH:28]=[CH:27][N:26]=1>>[CH:25]1[C:34]2[C:29](=[C:30]([N:35]3[C:5]([C:7]4[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]5[CH:19]=[CH:18][C:17]([S:20]([CH3:23])(=[O:22])=[O:21])=[CH:16][CH:15]=5)[N:8]=4)=[CH:4][CH:3]=[N:2]3)[CH:31]=[CH:32][CH:33]=2)[CH:28]=[CH:27][N:26]=1

Participants

3

Reactant 2

HCID 132664235-HydrazinylisoquinolineHCID 593701413-((E)-3-Dimethylamino-acryloyl)-1-(4-methansulfonyl-phenyl)-1H-pyridazin-4-one

Product 1

HCID 593701473-(2-Isoquinolin-5-yl-2H-pyrazol-3-yl)-1-(4-methanesulfonyl-phenyl)-1H-pyridazin-4-one

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(4-methansulfonyl-phenyl)-1H-pyridazin-4-one (A-16) and isoquinolin-5-yl-hydrazine according to the method described for example 43. MS: M=444.5 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-98a3b83a53d643fa9927c2093746063f
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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