4-Hydrazinoquinoline → N,N-Dimethyl-3-[4-oxo-3-(2-quinolin-4-yl-2H-pyrazol-3-yl)-4H-pyridazin-1-yl]-benzenesulfonamide

HRID 1924665Notes

Reaction equation

HRID 1924665 reaction equation
CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:15]=[C:16]([S:20]([N:23]([CH3:25])[CH3:24])(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=2)[N:8]=1)=O.[N:27]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[C:30]([NH:37][NH2:38])=[CH:29][CH:28]=1>>[CH3:25][N:23]([CH3:24])[S:20]([C:16]1[CH:17]=[CH:18][CH:19]=[C:14]([N:9]2[CH:10]=[CH:11][C:12](=[O:13])[C:7]([C:5]3[N:37]([C:30]4[C:31]5[C:36](=[CH:35][CH:34]=[CH:33][CH:32]=5)[N:27]=[CH:28][CH:29]=4)[N:38]=[CH:3][CH:4]=3)=[N:8]2)[CH:15]=1)(=[O:22])=[O:21]

Participants

3

Reactant 2

HCID 70204114-HydrazinoquinolineHCID 593701633-[3-((E)-3-Dimethylamino-acryloyl)-4-oxo-4H-pyridazin-1-yl]-N,N-dimethyl-benzenesulfonamide

Product 1

HCID 59370078N,N-Dimethyl-3-[4-oxo-3-(2-quinolin-4-yl-2H-pyrazol-3-yl)-4H-pyridazin-1-yl]-benzenesulfonamide

Procedure

The product was obtained starting from 3-[3-((E)-3-Dimethylamino-acryloyl)-4-oxo-4H-pyridazin-1-yl]-N,N-dimethyl-benzenesulfonamide (A-12) and quinolin-4-yl-hydrazine according to the method described for example 91. MS: M=473.3 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-2a27c0ed49774af8a4e1550a5bd1fe00
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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