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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1924672Generated: October 31, 2026

5-Hydrazinylquinoline → 3-(2-Quinolin-5-yl-2H-pyrazol-3-yl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

https://huagongshe.com/reaction/1924672

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-HydrazinylquinolineHCID 5200451—
Reactant3-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-oneHCID 59370123—
Product3-(2-Quinolin-5-yl-2H-pyrazol-3-yl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-oneHCID 59370135—

Reaction Steps

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one (A-6) and quinolin-5-yl-hydrazine according to the method described for example 91. MS: M=450.1 (M+H)+

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08178538B2
Source datasetuspto-grants-2012_05
ORD IDord-dcc56dafd5bd479d858f0a812b953d89
Source noteuspto-grants-2012_05