4-Hydrazinoquinoline → 3-[4-Oxo-3-(2-quinolin-4-yl-2H-pyrazol-3-yl)-4H-pyridazin-1-yl]-benzonitrile

HRID 1924676Notes

Reaction equation

C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=2)[C:17]#[N:18])[N:8]=1)=O.[N:23]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:26]([NH:33]N)=[CH:25][CH:24]=1>>[O:13]=[C:12]1[CH:11]=[CH:10][N:9]([C:14]2[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=2)[C:17]#[N:18])[N:8]=[C:7]1[C:5]1[N:33]([C:26]2[C:27]3[C:32](=[CH:31][CH:30]=[CH:29][CH:28]=3)[N:23]=[CH:24][CH:25]=2)[N:2]=[CH:3][CH:4]=1

Participants

Reactant 2

HCID 70204114-Hydrazinoquinoline

HCID 59370150HCID 59370150, compound

Product 1

HCID 462204733-[4-Oxo-3-(2-quinolin-4-yl-2H-pyrazol-3-yl)-4H-pyridazin-1-yl]-benzonitrile

Procedure

The product was obtained starting from 3-[3-((E)-3-Dimethylamino-acryloyl)-4-oxo-4H-pyridazin-1-yl]-benzonitrile (A-19) and quinolin-4-yl-hydrazine according to the method described for example 91. MS: M=391.1 (M+H)+

Workup

customThe product was obtained

Sources & evidence

ORD record: ord-f045a02192f14bd6811c63c2899cf4ba
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08178538B2

Reaction notes

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