6-Chloro-4-hydrazinoquinoline → 3-[2-(6-Chloro-quinolin-4-yl)-2H-pyrazol-3-yl]-1-(4-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

HRID 1924692Notes

Reaction equation

HRID 1924692 reaction equation
CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=2)[N:8]=1)=O.[Cl:26][C:27]1[CH:28]=[C:29]2[C:34](=[CH:35][CH:36]=1)[N:33]=[CH:32][CH:31]=[C:30]2[NH:37][NH2:38]>>[Cl:26][C:27]1[CH:28]=[C:29]2[C:34](=[CH:35][CH:36]=1)[N:33]=[CH:32][CH:31]=[C:30]2[N:37]1[C:5]([C:7]2[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]3[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=3)[N:8]=2)=[CH:4][CH:3]=[N:38]1

Participants

3

Reactant 2

HCID 124435306-Chloro-4-hydrazinoquinolineHCID 593700343-((E)-3-Dimethylamino-acryloyl)-1-(4-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

Product 1

HCID 593701153-[2-(6-Chloro-quinolin-4-yl)-2H-pyrazol-3-yl]-1-(4-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(4-trifluoromethoxy-phenyl)-1H-pyridazin-4-one (A-8) and (6-chloro-quinolin-4-yl)-hydrazine according to the method described for example 91. MS: M=484.1 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-9e981552acbe4bad99b9e221561f5443
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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