HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Hydrazinylisoquinoline → 3-(2-Isoquinolin-5-yl-2H-pyrazol-3-yl)-1-(4-trifluoromethoxy-phenyl)-1H-pyridazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Hydrazinylisoquinoline | HCID 13266423 | — |
| Reactant | 3-((E)-3-Dimethylamino-acryloyl)-1-(4-trifluoromethoxy-phenyl)-1H-pyridazin-4-one | HCID 59370034 | — |
| Product | 3-(2-Isoquinolin-5-yl-2H-pyrazol-3-yl)-1-(4-trifluoromethoxy-phenyl)-1H-pyridazin-4-one | HCID 59369973 | — |
Reaction Steps
The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(4-trifluoromethoxy-phenyl)-1H-pyridazin-4-one (A-8) and isoquinolin-5-yl-hydrazine according to the method described for example 91. MS: M=450.1 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178538B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-bbe9fc0549eb4b679ed343cf2ee356e9 |
| Source note | uspto-grants-2012_05 |