2-Fluorophenylhydrazine hydrochloride → 3-[2-(2-Fluoro-phenyl)-2H-pyrazol-3-yl]-1-[3-(piperidine-1-sulfonyl)-phenyl]-1H-pyridazin-4-one

HRID 1924699Notes

Reaction equation

HRID 1924699 reaction equation
CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([N:23]3[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)(=[O:22])=[O:21])[CH:15]=2)[N:8]=1)=O.[F:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[NH:37][NH2:38]>>[F:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[N:37]1[C:5]([C:7]2[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([N:23]4[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]4)(=[O:21])=[O:22])[CH:15]=3)[N:8]=2)=[CH:4][CH:3]=[N:38]1

Participants

3

Reactant 2

HCID 4238442-Fluorophenylhydrazine hydrochlorideHCID 593701133-((E)-3-Dimethylamino-acryloyl)-1-[3-(piperidine-1-sulfonyl)-phenyl]-1H-pyridazin-4-one

Product 1

HCID 593701393-[2-(2-Fluoro-phenyl)-2H-pyrazol-3-yl]-1-[3-(piperidine-1-sulfonyl)-phenyl]-1H-pyridazin-4-one

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-[3-(piperidine-1-sulfonyl)-phenyl]-1H-pyridazin-4-one (A-26) and 2-fluoro-phenylhydrazine according to the method described for example 91. MS: M=480.1 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-aa30945a04d4466685bcb57ffde5a64a
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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