5-Hydrazinylquinoline → 3-(2-Quinolin-5-yl-2H-pyrazol-3-yl)-1-(4-trifluoromethanesulfonyl-phenyl)-1H-pyridazin-4-one

HRID 1924703Notes

Reaction equation

HRID 1924703 reaction equation
CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][C:17]([S:20]([C:23]([F:26])([F:25])[F:24])(=[O:22])=[O:21])=[CH:16][CH:15]=2)[N:8]=1)=O.[N:28]1[C:37]2[C:32](=[C:33]([NH:38][NH2:39])[CH:34]=[CH:35][CH:36]=2)[CH:31]=[CH:30][CH:29]=1>>[N:28]1[C:37]2[C:32](=[C:33]([N:38]3[C:5]([C:7]4[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]5[CH:19]=[CH:18][C:17]([S:20]([C:23]([F:26])([F:24])[F:25])(=[O:22])=[O:21])=[CH:16][CH:15]=5)[N:8]=4)=[CH:4][CH:3]=[N:39]3)[CH:34]=[CH:35][CH:36]=2)[CH:31]=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 52004515-HydrazinylquinolineHCID 593701663-((E)-3-Dimethylamino-acryloyl)-1-(4-trifluoromethansulfonyl-phenyl)-1H-pyridazin-4-one

Product 1

HCID 593700593-(2-Quinolin-5-yl-2H-pyrazol-3-yl)-1-(4-trifluoromethanesulfonyl-phenyl)-1H-pyridazin-4-one

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(4-trifluoromethansulfonyl-phenyl)-1H-pyridazin-4-one (A-27) and quinolin-5-yl-hydrazine according to the method described for example 43. MS: M=498.1 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-e71e984f07a34922a10c4b69c916a358
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

Loading…