5-Hydrazinylquinoline → 1-[3-(Pyrrolidine-1-sulfonyl)-phenyl]-3-(2-quinolin-5-yl-2H-pyrazol-3-yl)-1H-pyridazin-4-one

HRID 1924718Notes

Reaction equation

CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([N:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)(=[O:22])=[O:21])[CH:15]=2)[N:8]=1)=O.[N:29]1[C:38]2[C:33](=[C:34]([NH:39][NH2:40])[CH:35]=[CH:36][CH:37]=2)[CH:32]=[CH:31][CH:30]=1>>[N:23]1([S:20]([C:16]2[CH:15]=[C:14]([N:9]3[CH:10]=[CH:11][C:12](=[O:13])[C:7]([C:5]4[N:39]([C:34]5[CH:35]=[CH:36][CH:37]=[C:38]6[C:33]=5[CH:32]=[CH:31][CH:30]=[N:29]6)[N:40]=[CH:3][CH:4]=4)=[N:8]3)[CH:19]=[CH:18][CH:17]=2)(=[O:22])=[O:21])[CH2:24][CH2:25][CH2:26][CH2:27]1

Participants

Reactant 2

HCID 52004515-Hydrazinylquinoline

HCID 59370023HCID 59370023, compound

Product 1

HCID 462203611-[3-(Pyrrolidine-1-sulfonyl)-phenyl]-3-(2-quinolin-5-yl-2H-pyrazol-3-yl)-1H-pyridazin-4-one

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-[3-(pyrrolidine-1-sulfonyl)-phenyl]-1H-pyridazin-4-one (A-29) and quinolin-5-yl-hydrazine according to the method described for example 91. MS: M=499.2 (M+H)+

Workup

customThe product was obtained

Sources & evidence

ORD record: ord-6f068b0bf51641229e2ac9682d62e836
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08178538B2

Reaction notes

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