5-Hydrazinylisoquinoline → 3-[3-(2-Isoquinolin-5-yl-2H-pyrazol-3-yl)-4-oxo-4H-pyridazin-1-yl]-N-methyl-benzenesulfonamide

HRID 1924731Notes

Reaction equation

C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:15]=[C:16]([S:20]([NH:23][CH3:24])(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=2)[N:8]=1)=O.[CH:26]1[C:35]2[C:30](=[C:31]([NH:36]N)[CH:32]=[CH:33][CH:34]=2)[CH:29]=[CH:28][N:27]=1>>[CH:26]1[C:35]2[C:30](=[C:31]([N:36]3[C:5]([C:7]4[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]5[CH:15]=[C:16]([S:20]([NH:23][CH3:24])(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=5)[N:8]=4)=[CH:4][CH:3]=[N:2]3)[CH:32]=[CH:33][CH:34]=2)[CH:29]=[CH:28][N:27]=1

Participants

Reactant 2

HCID 132664235-Hydrazinylisoquinoline

HCID 59370003HCID 59370003, compound

Product 1

HCID 593700823-[3-(2-Isoquinolin-5-yl-2H-pyrazol-3-yl)-4-oxo-4H-pyridazin-1-yl]-N-methyl-benzenesulfonamide

Procedure

The product was obtained starting from 3-[3-((E)-3-Dimethylamino-acryloyl)-4-oxo-4H-pyridazin-1-yl]-N-methyl-benzenesulfonamide (A-31) and isoquinolin-5-yl-hydrazine according to the method described for example 91. MS: M=459.3 (M+H)+

Workup

customThe product was obtained

Sources & evidence

ORD record: ord-75b03be8151b45d99bee2255a6f7f67c
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08178538B2

Reaction notes

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