5-Hydrazinylisoquinoline → 3-(2-Isoquinolin-5-yl-2H-pyrazol-3-yl)-1-[3-(piperidine-1-sulfonyl)-phenyl]-1H-pyridazin-4-one

HRID 1924734Notes

Reaction equation

HRID 1924734 reaction equation
CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([N:23]3[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)(=[O:22])=[O:21])[CH:15]=2)[N:8]=1)=O.[CH:30]1[C:39]2[C:34](=[C:35]([NH:40][NH2:41])[CH:36]=[CH:37][CH:38]=2)[CH:33]=[CH:32][N:31]=1>>[CH:30]1[C:39]2[C:34](=[C:35]([N:40]3[C:5]([C:7]4[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]5[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([N:23]6[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]6)(=[O:22])=[O:21])[CH:15]=5)[N:8]=4)=[CH:4][CH:3]=[N:41]3)[CH:36]=[CH:37][CH:38]=2)[CH:33]=[CH:32][N:31]=1

Participants

3

Reactant 2

HCID 132664235-HydrazinylisoquinolineHCID 593701133-((E)-3-Dimethylamino-acryloyl)-1-[3-(piperidine-1-sulfonyl)-phenyl]-1H-pyridazin-4-one

Product 1

HCID 462204683-(2-Isoquinolin-5-yl-2H-pyrazol-3-yl)-1-[3-(piperidine-1-sulfonyl)-phenyl]-1H-pyridazin-4-one

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-[3-(piperidine-1-sulfonyl)-phenyl]-1H-pyridazin-4-one (A-26) and isoquinolin-5-yl-hydrazine according to the method described for example 91. MS: M=513.4 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-7153fb7cbc7e41d980191e384ef9578b
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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