2-Fluorophenylhydrazine hydrochloride → N,N-Diethyl-3-{3-[2-(2-fluoro-phenyl)-2H-pyrazol-3-yl]-4-oxo-4H-pyridazin-1-yl}-benzenesulfonamide

HRID 1924737Notes

Reaction equation

HRID 1924737 reaction equation
CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:15]=[C:16]([S:20]([N:23]([CH2:26][CH3:27])[CH2:24][CH3:25])(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=2)[N:8]=1)=O.[F:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1[NH:36][NH2:37]>>[CH2:24]([N:23]([CH2:26][CH3:27])[S:20]([C:16]1[CH:17]=[CH:18][CH:19]=[C:14]([N:9]2[CH:10]=[CH:11][C:12](=[O:13])[C:7]([C:5]3[N:36]([C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=4[F:29])[N:37]=[CH:3][CH:4]=3)=[N:8]2)[CH:15]=1)(=[O:22])=[O:21])[CH3:25]

Participants

3

Reactant 2

HCID 4238442-Fluorophenylhydrazine hydrochlorideHCID 593700613-[3-((E)-3-Dimethylamino-acryloyl)-4-oxo-4H-pyridazin-1-yl]-N,N-diethyl-benzenesulfonamide

Product 1

HCID 59370092N,N-Diethyl-3-{3-[2-(2-fluoro-phenyl)-2H-pyrazol-3-yl]-4-oxo-4H-pyridazin-1-yl}-benzenesulfonamide

Procedure

The product was obtained starting from 3-[3-((E)-3-Dimethylamino-acryloyl)-4-oxo-4H-pyridazin-1-yl]-N,N-diethyl-benzenesulfonamide (A-21) and 2-fluoro-phenylhydrazine according to the method described for example 91. MS: M=468.2 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-a70a936bce054795a7e5b89b64fdd8e8
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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