(3-Fluorophenyl)hydrazine → 3-[2-(3-Fluoro-phenyl)-2H-pyrazol-3-yl]-1-[3-(piperidine-1-sulfonyl)-phenyl]-1H-pyridazin-4-one

HRID 1924741Notes

Reaction equation

HRID 1924741 reaction equation
CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([N:23]3[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)(=[O:22])=[O:21])[CH:15]=2)[N:8]=1)=O.[F:30][C:31]1[CH:32]=[C:33]([NH:37][NH2:38])[CH:34]=[CH:35][CH:36]=1>>[F:30][C:31]1[CH:32]=[C:33]([N:37]2[C:5]([C:7]3[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]4[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([N:23]5[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]5)(=[O:21])=[O:22])[CH:15]=4)[N:8]=3)=[CH:4][CH:3]=[N:38]2)[CH:34]=[CH:35][CH:36]=1

Participants

3

Reactant 2

HCID 581026(3-Fluorophenyl)hydrazineHCID 593701133-((E)-3-Dimethylamino-acryloyl)-1-[3-(piperidine-1-sulfonyl)-phenyl]-1H-pyridazin-4-one

Product 1

HCID 593700983-[2-(3-Fluoro-phenyl)-2H-pyrazol-3-yl]-1-[3-(piperidine-1-sulfonyl)-phenyl]-1H-pyridazin-4-one

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-[3-(piperidine-1-sulfonyl)-phenyl]-1H-pyridazin-4-one (A-26) and 3-fluoro-phenylhydrazine according to the method described for example 91. MS: M=480.1 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-fac02ad6db244f118e9b825195da435f
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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