2-Fluorophenylhydrazine hydrochloride → 3-[2-(2-Fluoro-phenyl)-2H-pyrazol-3-yl]-1-(3-trifluoromethanesulfonyl-phenyl)-1H-pyridazin-4-one

HRID 1924750Notes

Reaction equation

HRID 1924750 reaction equation
CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([C:23]([F:26])([F:25])[F:24])(=[O:22])=[O:21])[CH:15]=2)[N:8]=1)=O.[F:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[NH:35][NH2:36]>>[F:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[N:35]1[C:5]([C:7]2[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([S:20]([C:23]([F:26])([F:24])[F:25])(=[O:21])=[O:22])[CH:15]=3)[N:8]=2)=[CH:4][CH:3]=[N:36]1

Participants

3

Reactant 2

HCID 4238442-Fluorophenylhydrazine hydrochlorideHCID 593701323-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethansulfonyl-phenyl)-1H-pyridazin-4-one

Product 1

HCID 462204703-[2-(2-Fluoro-phenyl)-2H-pyrazol-3-yl]-1-(3-trifluoromethanesulfonyl-phenyl)-1H-pyridazin-4-one

Procedure

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethansulfonyl-phenyl)-1H-pyridazin-4-one (A-33) and 2-fluoro-phenylhydrazine according to the method described for example 1. MS: M=465.1 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-9f915f503eba46b392059aac7962afb4
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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