Fluoromethyl 4-methylbenzenesulfonate → HCID 59370024, compound

HRID 1924757Notes

Reaction equation

HRID 1924757 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([N:8]2[CH:13]=[CH:12][C:11](=[O:14])[C:10]([C:15]3[N:16]([C:20]4[C:29]5[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=5)[CH:23]=[CH:22][CH:21]=4)[N:17]=[CH:18][CH:19]=3)=[N:9]2)[CH:5]=[CH:6][CH:7]=1.S(C1C=CC(C)=CC=1)(O[CH2:34][F:35])(=O)=O>>[F:35][CH2:34][O:1][C:2]1[CH:3]=[C:4]([N:8]2[CH:13]=[CH:12][C:11](=[O:14])[C:10]([C:15]3[N:16]([C:20]4[C:29]5[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=5)[CH:23]=[CH:22][CH:21]=4)[N:17]=[CH:18][CH:19]=3)=[N:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 13862289Fluoromethyl 4-methylbenzenesulfonateHCID 59370028HCID 59370028, compound

Product 1

HCID 59370024HCID 59370024, compound

Procedure

The product was obtained starting from 1-(3-Hydroxy-phenyl)-3-(2-naphthalen-1-yl-2H-pyrazol-3-yl)-1H-pyridazin-4-one (example 276) and fluoromethyl tosylate according to the method described in example 290. MS: M=413.1 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-a5281d41213e4ab4adf32348d660b75d
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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