HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 59369950, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 2-Fluoroethanol | HCID 9737 | — |
| Reactant | 1-(3-Bromo-phenyl)-3-(2-naphthalen-1-yl-2H-pyrazol-3-yl)-1H-pyridazin-4-one | HCID 59370097 | — |
| Reactant | HCID 178418416 | HCID 178418416 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Product | HCID 59369950 | HCID 59369950 | 67% |
Reaction Steps
1-(3-Bromo-phenyl)-3-(2-naphthalen-1-yl-2H-pyrazol-3-yl)-1H-pyridazin-4-one (example 190) (100 mg, 0.23 mmol) was dissolved in EtOAc (3 ml) and the solution was placed in the reaction vessel. [PdCl2(dppf)] (10 mg) was added followed by 2-fluoroethanol (97 mg, 1.5 mmol) and Et3N (0.05 ml). The reactor was closed and the mixture was stirred 20 h under 70 bar carbon monoxide at 110° C. After evaporation of the solvents the residue was purified by chromatography (10 g SiO2, Hept to Hept/EtOAc 1:1). The product was isolated as an off-white solid (69 mg, 67%). MS: M=455.1 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178538B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-33bc4a9aa7574fcc919a5367e76de3da |
| Source note | uspto-grants-2012_05 |