HCID 59370165, compound → HCID 59370143, compound

HRID 1924763Notes

Reaction equation

HRID 1924763 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([C:13]2[C:18](=[O:19])[CH:17]=[CH:16][N:15]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([CH:26]([OH:28])[CH3:27])[CH:21]=3)[N:14]=2)=[CH:11][CH:10]=[N:9]1>ClCCl.[O-2].[O-2].[Mn+4]>[C:26]([C:22]1[CH:21]=[C:20]([N:15]2[CH:16]=[CH:17][C:18](=[O:19])[C:13]([C:12]3[N:8]([C:3]4[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=4[F:1])[N:9]=[CH:10][CH:11]=3)=[N:14]2)[CH:25]=[CH:24][CH:23]=1)(=[O:28])[CH3:27]

Participants

4

Reactant 1

HCID 59370165HCID 59370165, compound

Product 1

HCID 59370143HCID 59370143, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

The product was obtained starting from 3-[2-(2-Fluoro-phenyl)-2H-pyrazol-3-yl]-1-[3-(1-hydroxy-ethyl)-phenyl]-1H-pyridazin-4-one (example 298) by treatment with manganese dioxide in dichloromethane at room temperature for 6 h. MS: M=375.1 (M+H)+

Workup

  1. customThe product was obtained

Sources & evidence

ORD record
ord-2f52f45cbb754cb58e602aaf666a78db
Source dataset
uspto-grants-2012_05
Patent number
US08178538B2

Reaction notes

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