HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → 4-(2-hydroxypropan-2-yl)-N-(5-(1-methyl-1H-pyrazol-5-yl)thiazolo[5,4-b]pyridin-2-yl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole | HCID 4912908 | — |
| Reactant | N-(5-bromothiazolo[5,4-b]pyridin-2-yl)-4-(2-hydroxypropan-2-yl)benzamide | HCID 58015365 | — |
| Product | 4-(2-hydroxypropan-2-yl)-N-(5-(1-methyl-1H-pyrazol-5-yl)thiazolo[5,4-b]pyridin-2-yl)benzamide | HCID 44549071 | 4% |
Reaction Steps
The titled compound (yield=4%) was prepared using a procedure analogous to that described in connection with 9 (Example 9) except 1D (Example 1) and 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole were used as starting materials. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.47 (s, 6H) 4.20 (s, 3H) 6.86 (d, J=1.26 Hz, 1H) 7.52 (d, J=1.26 Hz, 1H) 7.67 (d, J=8.08 Hz, 2H) 7.92 (d, J=8.59 Hz, 1H) 8.11 (d, J=8.34 Hz, 2H) 8.23 (d, J=8.34 Hz, 1H) 13.03 (s, 1H);); ESI-MS: m/z 394.0 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178555B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-772cdbabd46c46bf8f58854ffab51646 |
| Source note | uspto-grants-2012_05 |