Methyl 4-(5-bromothiazolo[5,4-b]pyridin-2-ylcarbamoyl)benzoate → HCID 178497988, compound

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Reaction Steps

The titled compound (yield=17%, yellow solid) was prepared using a procedure analogous to that described in connection with 9 (Example 9) except 1C (Example 3) and 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole were used as starting materials. 1H NMR (400 MHz, DMSO-d6) δ ppm 2.58 (s, 3H) 3.91 (s, 3H) 6.56 (br. s., 1H) 7.76 (d, J=8.59 Hz, 1H) 8.12 (d, J=8.59 Hz, 4H) 8.25 (d, J=8.59 Hz, 2H) 13.15 (br. s., 1H); ESI-MS: m/z 394.0 (M+H)+.

Provenance & Evidence