HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 5,5-Diethyl-3-methyl-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 5,5-Diethyl-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid | HCID 57508891 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5,5-Diethyl-3-methyl-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid | HCID 67520368 | — |
Reaction Steps
5,5-Diethyl-3-methyl-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid is prepared from 5,5-diethyl-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid by treatment with tert.-BuLi followed by methyliodide in analogy to Example C; LC-MS: tR=1.03 min, [M+1+CH3CN]=294.27.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178562B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-be553fbb789641f38f249a5e54e85647 |
| Source note | uspto-grants-2012_05 |