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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1924817Generated: November 1, 2026

Iodoethane → 3,5,5-Triethyl-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid

https://huagongshe.com/reaction/1924817

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIodoethaneHCID 6340—
Reactant5,5-Diethyl-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acidHCID 57508891—
ReactantButyllithiumHCID 178418339—
SolventAcetonitrileHCID 6342—
Product3,5,5-Triethyl-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acidHCID 67520366—

Reaction Steps

3,5,5-Triethyl-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid is prepared from 5,5-diethyl-4,5,6,7-tetrahydro-benzo[c]thiophene-1-carboxylic acid by treatment with tert.-BuLi followed by ethyliodide in analogy to Example C; LC-MS: tR=1.07 min, [M+1+CH3CN]=308.14.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08178562B2
Source datasetuspto-grants-2012_05
ORD IDord-a0b9134a234f49eb9c5d0abc7621159a
Source noteuspto-grants-2012_05