HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-Ethyl-6-methylisonicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 2-Ethyl-6-methylisonicotinic acid tert-butyl ester | HCID 67026967 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Ethyl-6-methylisonicotinic acid | HCID 58418097 | — |
Reaction Steps
A solution of 2-ethyl-6-methyl-isonicotinic acid tert-butyl ester in DCM (10 mL) is treated with TFA (10 mL) and the mixture stirred at rt for 0.5 h. The mixture is evaporated and the residue dried under HV to give 2-ethyl-6-methyl-isonicotinic acid; LC-MS: tR=0.28 min, [M+1]+=166.25.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178562B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-0d71d41080a440b3b79f934fde57afcb |
| Source note | uspto-grants-2012_05 |