HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1924864Generated: October 31, 2026
Tetrahydro-2H-pyran-4-yl 4-methylbenzenesulfonate → S-Tetrahydro-2H-pyran-4-YL ethanethioate
https://huagongshe.com/reaction/1924864
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrahydro-2H-pyran-4-yl 4-methylbenzenesulfonate | HCID 13961807 | — |
| Reactant | Potassium ethanethioate | HCID 23670855 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | S-Tetrahydro-2H-pyran-4-YL ethanethioate | HCID 18533108 | — |
Reaction Steps
A mixture of potassium thioacetate (10.21 g; 87.62 mmol) and toluene-4-sulfonic acid tetrahydro-pyran-4-yl ester (11.23 g; 43.81 mmol) in DMF (100 mL) was heated at 50° C. for 12 hours, cooled to room temperature, diluted with ether, washed with water, saturated NaHCO3 and brine and dried (MgSO4). Removal of the volatiles in vacuo provided a residue which was taken forward without additional purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08178568B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-76cde16224864ccb931e60eada60c49d |
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| Source note | uspto-grants-2012_05 |
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