HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1924969Generated: October 31, 2026
Potassium Carbonate → 4H,5H,6H-thieno[2,3-c]pyrrol-6-one
https://huagongshe.com/reaction/1924969
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 3-(aminomethyl)thiophene-2-carboxylate | HCID 53419606 | — |
| Solvent | Ethanol, mixt. with methanol | HCID 18681192 | — |
| Product | 4H,5H,6H-thieno[2,3-c]pyrrol-6-one | HCID 20542805 | — |
Reaction Steps
To a solution of 3-aminomethyl-thiophene-2-carboxylic acid methyl ester (0.82 g, 4.79 mmol) in 1:1 MeOH-EtOH (125 mL), is added K2CO3 (0.66 g, 4.79 mmol) and the mixture is stirred at 90° C. for 5 hours. The solvent is removed in vacuo and the residue purified by silica gel column chromatography eluting with 97:3 DCM:MeOH. The title compound is isolated (0.365 g, 55%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08178530B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-5ae8e46379d240868d75df4c096710e6 |
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| Source note | uspto-grants-2012_05 |
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