HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylacetyl chloride → N-(5-nitropyridin-2-yl)-2-phenylacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylacetyl chloride | HCID 7679 | — |
| Reactant | 2-Amino-5-nitropyridine | HCID 77888 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(5-nitropyridin-2-yl)-2-phenylacetamide | HCID 4350143 | — |
Reaction Steps
A solution of 2-amino-5-nitropyridine (4.17 g, 30 mmol) in pyridine (30 mL) is stirred at rt and a solution of phenylacetyl chloride (4.64 g, 30 mmol) in THF (30 mL) is added dropwise. The mixture is stirred for 24 h and then poured into ice-water (250 mL) to afford a brown solid, which is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178530B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-70c1396ac5d94286907f49fd6b84f93b |
| Source note | uspto-grants-2012_05 |