6-(4-Isopropyl-piperazin-1-yl)-pyridin-3-yl-amine → [6-(4-Isopropylpiperazin-1-yl)pyridin-3-yl]-[5-(1H-pyrazol-4-yl)-imidazo[1,2-a]pyrazin-8-yl]amine

HRID 1924973Notes

Reaction equation

HRID 1924973 reaction equation
COC1C=C(N[C:21]2[C:22]3[N:23]([CH:32]=[CH:33][N:34]=3)[C:24]([C:27]3[CH:28]=[N:29][NH:30][CH:31]=3)=[CH:25][N:26]=2)C=CC=1C(NCC1C=NC(C)=CC=1)=O.[CH:35]([N:38]1[CH2:43][CH2:42][N:41]([C:44]2[N:49]=[CH:48][C:47]([NH2:50])=[CH:46][CH:45]=2)[CH2:40][CH2:39]1)([CH3:37])[CH3:36]>>[CH:35]([N:38]1[CH2:39][CH2:40][N:41]([C:44]2[N:49]=[CH:48][C:47]([NH:50][C:21]3[C:22]4[N:23]([CH:32]=[CH:33][N:34]=4)[C:24]([C:27]4[CH:28]=[N:29][NH:30][CH:31]=4)=[CH:25][N:26]=3)=[CH:46][CH:45]=2)[CH2:42][CH2:43]1)([CH3:37])[CH3:36]

Participants

3

Reactant 2

HCID 434620426-(4-Isopropyl-piperazin-1-yl)-pyridin-3-yl-amineHCID 590230222-Methoxy-N-(6-methylpyridin-3-ylmethyl)-4-[5-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-ylamino]benzamide

Product 1

HCID 59023014[6-(4-Isopropylpiperazin-1-yl)pyridin-3-yl]-[5-(1H-pyrazol-4-yl)-imidazo[1,2-a]pyrazin-8-yl]amine

Procedure

This compound may be prepared using the same methods as described for Compound 184, using 6-(4-isopropylpiperazin-1-yl)pyridin-3-ylamine in Step 3. LCMS: Rt=0.72 min (95%), m/z (ESI) 404 (M+H)+.

Workup

  1. customThis compound may be prepared

Sources & evidence

ORD record
ord-a7cac3f601894b87a20d549601b5ed2b
Source dataset
uspto-grants-2012_05
Patent number
US08178530B2

Reaction notes

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