HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 5-Bromo-2-[(4-methoxy-benzylamino)-methyl]-furan-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 5-Bromo-2-[(4-methoxy-benzylamino)-methyl]-furan-3-carboxylic acid methyl ester | HCID 59023123 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Bromo-2-[(4-methoxy-benzylamino)-methyl]-furan-3-carboxylic acid | HCID 59023023 | 100.1% |
Reaction Steps
A solution of 5-bromo-2-[(4-methoxy-benzylamino)-methyl]-furan-3-carboxylic acid methyl ester (643.8 mg, 1.82 mmol) and LiOH (115 mg, 2.74 mmol) in 1:1 THF:H2O (30 mL) is refluxed for 3 hours. The solvent is evaporated in vacuo to afford the title compound (620 mg, 99%) which is used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178530B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-4a7b6472c0f04fb49e56d4b86e9da017 |
| Source note | uspto-grants-2012_05 |