Hydrochloric Acid → 5-(1-methyl-1H-pyrazol-4-yl)-2,4(1H,3H)-pyrimidinedione hydrochloride

Participants

Reaction Conditions

Reaction Steps

2,4-bis(methyloxy)-5-(1-methyl-1H-pyrazol-4-yl)pyrimidine (Prep28, 483.7 mg, 1.977 mmol) was suspended in 4M solution of HCl in 1,4-dioxane (10 mL, 40.0 mmol) to give a white suspension. After 1 h at 90° C., 5 ml of 4M solution of HCl in 1,4-dioxane (5 mL, 20.0 mmol) were then added and the reaction mixture was vigorously stirred at 90° C. Again, 5 ml of 4M solution of HCl in 1,4-dioxane (5 mL, 20.0 mmol) were added and the reaction mixture was vigorously stirred at 90° C. overnight. The solvent was evaporated to obtain 508.4 mg of the title compound as a white solid.

Provenance & Evidence