Hydrochloric Acid → 5-(2,4-dimethyl-1,3-thiazol-5-yl)-2,4(1H,3H)-pyrimidinedione

Participants

Reaction Steps

5-(2,4-dimethyl-1,3-thiazol-5-yl)-2,4-bis(methyloxy)pyrimidine (521 mg, 2.073 mmol) was dissolved in Methanol (30 ml), then 1N Hydrochloric acid aqueous solution (16.59 ml, 16.59 mmol) was added and the mixture was refluxed for 3 hours. Solvents were then evaporated under reduced pressure, the residue was triturated with acetone and filtered providing the title compound (507 mg, 2.27 mmol) as a white solid.

Provenance & Evidence