Hydrochloric Acid → 3-[5-(4-methyl-1,3-thiazol-2-yl)-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]propanal

Participants

Reaction Steps

To a solution of 1-[3,3-bis(methyloxy)propyl]-5-(4-methyl-1,3-thiazol-2-yl)-2,4(1H,3H)-pyrimidinedione (Pre 44, 34 mg, 0.109 mmol) in Tetrahydrofuran (THF) (1.5 ml) 1M aqueous HCl (0.546 ml, 0.546 mmol) was added and the mixture was stirred at rt for 5 hrs. Other 1M aqueous HCl (0.273 ml, 0.273 mmol) was added and the mixture was stirred at rt overnight. Volatiles were evaporated (rotary, cold bath) and the residue was taken up with TEA (0.122 ml, 0.874 mmol) and THF (3 mL). The slurry was evaporated to dryness (rotary) to afford a crude that was used in the next reaction step assuming quantitative conversion to target compound (0.109 mmol) without any further purification

Provenance & Evidence