Hydrochloric Acid → 5-[3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl]-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione dihydrochloride

Participants

Reaction Steps

5-[3-(trifluoromethyl)-6,7-dihydropyrano[4,3-c]pyrazol-1(4H)-yl]-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione (E22, 9.6 mg, 0.014 mmol) was dissolved and sonicated in Diethyl ether (2 ml) to give a pale yellow solution. 1.25 M solution of HCl in MeOH (0.029 ml, 0.036 mmol) was added at room temperature. The obtained mixture was sonicated for 3 min and the solvent evaporated in vacuo. Obtained 10.1 mg (99% yield) of the title compound as a white solid.

Provenance & Evidence