Hydrochloric Acid → 5-(3-methyl-4-isothiazolyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione hydrochloride

Participants

Reaction Steps

5-(3-methyl-4-isothiazolyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione (E41, 8.7 mg, 0.018 mmol) in Et2O (0.5 mL) was treated with HCl (0.022 ml, 0.022 mmol) 1M in Et2O. The white solid formed was triturated with Et2O (2×0.3 mL) and dried to afford the title compound as a white solid (8.3 mg, 84% yield)

Provenance & Evidence