HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Amino-3-chloropyridazine → N-(6-chloroimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Amino-3-chloropyridazine | HCID 21643 | — |
| Reactant | Potassium Phosphate, Dibasic | HCID 24450 | — |
| Reactant | N-(2-bromoacetyl)cyclopropanecarboxamide | HCID 59233013 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | N-(6-chloroimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide | HCID 59232980 | — |
Reaction Steps
6-Chloropyridazin-3-amine, N-(2-bromoacetyl)cyclopropanecarboxamide, and potassium hydrogenphosphate were mixed in DMA at 75° C. to provide N-(6-chloroimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide. N-(6-chloroimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide was reacted with [1,2,4]triazolo[4,3-a]pyridine-3-thiol and K2CO3 in DMA at 145° C. and 100 psi N2 to provide N-(6-([1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclo-propanecarboxamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178534B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-c69b953895964050a1097aa78876eab9 |
| Source note | uspto-grants-2012_05 |