Ammonia methanol → HCID 86639818, compound

HRID 1925113Notes

Reaction equation

HRID 1925113 reaction equation
[Br:1][CH2:2][C:3]1[N:4]=[N:5][C:6]([Cl:9])=[CH:7][CH:8]=1.[NH3:10].CO>CO>[BrH:1].[Cl:9][C:6]1[N:5]=[N:4][C:3]([CH2:2][NH2:10])=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 21705897Ammonia methanolHCID 230809253-(Bromomethyl)-6-chloropyridazine

Product 1

HCID 86639818HCID 86639818, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of compound 10B (2.08 g, 10 mmol) in methanol (50 mL) was added into a pre-saturated ammonia/methanol solution (200 mL) at 0° C. The reaction solution was sealed and stirred at room temperature overnight. The methanol solution was concentrated and dried in vacuum to give 2.2 g of crude product (10C) as hydrobromide salt, which was used in next step without further purification. ESI-MS:m/z 144.1 (M+H)+.

Workup

  1. customThe reaction solution was sealed
  2. concentrationThe methanol solution was concentrated
  3. customdried in vacuum

Sources & evidence

ORD record
ord-e5a77cd1d89b40ac9489027d89b59e7f
Source dataset
uspto-grants-2012_05
Patent number
US08178534B2

Reaction notes

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