反应详情

A solution of compound 10B (2.08 g, 10 mmol) in methanol (50 mL) was added into a pre-saturated ammonia/methanol solution (200 mL) at 0° C. The reaction solution was sealed and stirred at room temperature overnight. The methanol solution was concentrated and dried in vacuum to give 2.2 g of crude product (10C) as hydrobromide salt, which was used in next step without further purification. ESI-MS:m/z 144.1 (M+H)+.

1. customThe reaction solution was sealed
2. concentrationThe methanol solution was concentrated
3. customdried in vacuum