N-(6-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide → 3-(2-(Cyclopropanecarboxamido)imidazo[1,2-b]pyridazin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid

Participants

Reaction Steps

Compound 33 was prepared from 3-mercapto-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid following the procedure described in the synthesis of compound 4. 1H NMR (400 MHz, CDCl3—CD3OD 10:1) δ ppm 9.03 (bs, 1 H), 8.01 (d, J=9.1 Hz, 1 H), 7.87 (d, J=9.6 Hz, 1 H), 7.68 (d, J=9.4 Hz, 1 H), 7.36 (m, 1H), 7.09 (d, J=9.3 Hz, 1 H), 2.84 (m, 1 H), 1.72 (m, 1 H), 0.97 (m, 2 H), 0.84 (m, 2H) ESI-MS:m/z 396.1 (M+H)+.

Provenance & Evidence