2-Hydrazinyl-5-Methylpyridine → HCID 59233292, compound

HRID 1925159Notes

Reaction equation

HRID 1925159 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH:11]([C:13]3[CH:14]=[CH:15][C:16]4[N:17]([CH:19]=[C:20]([NH:22][C:23]([CH:25]5[CH2:27][CH2:26]5)=[O:24])[N:21]=4)[N:18]=3)[CH3:12])=[N:9][N:10]=2)[CH:7]=1.N([C:30]1C=CC(C)=CN=1)N>>[CH3:30][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH:11]([C:13]3[CH:14]=[CH:15][C:16]4[N:17]([CH:19]=[C:20]([NH:22][C:23]([CH:25]5[CH2:26][CH2:27]5)=[O:24])[N:21]=4)[N:18]=3)[CH3:12])=[N:9][N:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 41533962-Hydrazinyl-5-MethylpyridineHCID 59233190HCID 59233190, compound

Product 1

HCID 59233292HCID 59233292, compound

Procedure

The title compound was synthesized using an analogous procedure to that described in the preparation of Compound 48 (Method A) using 2-hydrazinyl-5-methylpyridine. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.76-0.86 (m, 4 H) 1.85 (d, J=7.07 Hz, 3 H) 1.92 (m, 1 H) 3.56 (s, 3 H) 5.02 (d, J=7.07 Hz, 1 H) 7.18 (d, J=9.35 Hz, 1 H) 7.23-7.31 (m, 1 H) 7.70 (d, J=8.84 Hz, 1H) 7.93 (d, J=9.85 Hz, 1 H) 8.10 (s, 1 H) 8.20 (s, 1 H) 11.13 (s, 1 H). MS:m/z 362.2 (M+H)+.

Sources & evidence

ORD record
ord-d05654abc02043b1820ac9b28fd8aed2
Source dataset
uspto-grants-2012_05
Patent number
US08178534B2

Reaction notes

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