反应详情

温度

100 °C

A mixture of 6-(2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)propan-2-yl)pyridazin-3-amine 2,2,2-trifluoroacetate (50 mg, 0.136 mmol), N-(2-bromoacetyl)cyclopropanecarboxamide (28.0 mg, 0.136 mmol), sodium hydrogenphosphate (57.8 mg, 0.407 mmol), and potassium iodide (22.54 mg, 0.136 mmol) in DMA (Volume: 1160 μl) was heated in a microwave on high absorbance for 1 hr at 100° C. The reaction was purified by preparative LCMS to provide the title compound, (6-(2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)propan-2-yl)imidazo[1,2-b]pyridazin-2-yl)(cyclopropyl)methanone (54, 13 mg, 26%) as a TFA salt. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.81 (d, J=6.06 Hz, 4 H) 1.87-2.00 (m, 7 H) 6.92-6.97 (m, 1 H) 7.12 (d, J=9.60 Hz, 1 H) 7.55 (dd, J=8.97, 6.69 Hz, 1 H) 7.87-8.01 (m, 3H) 8.04 (s, 1 H) 11.16 (s, 1 H). ESI-MS:m/z 362.1 (M+H)+.

1. customThe reaction was purified by preparative LCMS