反应详情

A solution of 45 (100 mg) in 3N HCl:50% MeOH:water was heated at 50° C. for 3 hrs. The reaction was concentrated and purified by preparative LCMS to provide the title compound, 6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methyl)imidazo[1,2-b]pyridazin-2-amine (30 mg) as the TFA salt. 1H NMR (400 MHz, DMSO-d6) δ ppm 3.89 (s, 3 H) 7.46 (br. s., 1 H) 7.51-7.58 (m, 1 H) 7.90 (dd, J=9.47, 1.39 Hz, 1 H) 7.93-7.99 (m, 1 H) 8.04 (d, J=9.60 Hz, 1 H) 8.08 (s, 1 H) 8.39-8.43 (m, 2 H) 8.67 (s, 1 H). ESI-MS:m/z 382.2 (M+H)+.

1. concentrationThe reaction was concentrated
2. custompurified by preparative LCMS