HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenyl Isothiocyanate → HCID 178480032, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenyl Isothiocyanate | HCID 7673 | — |
| Reactant | HCID 59233289 | HCID 59233289 | — |
| Solvent | HCID 86639823 | HCID 86639823 | — |
| Product | HCID 59233289 | HCID 59233289 | — |
| Product | HCID 178480032 | HCID 178480032 | 86.3% |
Reaction Conditions
| Temperature | 160 °C |
|---|
Reaction Steps
5-(3-mercapto-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1-methylpyridin-2(]H)-one: A mixture of 5-(6-hydrazinylpyridin-3-yl)-1-methylpyridin-2(1 H)-one (600 mg, 2.78 mmol) and isothiocyanatobenzene (450 mg, 3.33 mmol) in NMP-1,3-dichlorobenzene (1:1, 10 mL) was heated in a microwave at 160° C. for 1 hr and then purified by preparative LCMS to provide the title compound, 5-(3-mercapto-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1-methylpyridin-2(1H)-one (310 mg, 43% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178534B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-983fb5141a7d4d5eb377986c56dd18b9 |
| Source note | uspto-grants-2012_05 |